Toyoaki Murohara Selected Research

Apolipoproteins

1/2022	Omentin attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice.
12/2017	Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice.
7/2015	Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
12/2014	Renin inhibition reduces atherosclerotic plaque neovessel formation and regresses advanced atherosclerotic plaques.
5/2011	High serum concentrations of pentosidine, an advanced glycation end product, are associated with low normal value of ankle-brachial index in apparently healthy men.
5/2011	Angiotensin type 1 receptor blocker reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.
6/2010	AT1 blockade attenuates atherosclerotic plaque destabilization accompanied by the suppression of cathepsin S activity in apoE-deficient mice.
5/2009	gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice.
4/2009	Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein e or low-density-lipoprotein receptor.
9/2006	Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5.

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Toyoaki Murohara Research Topics

Disease

118	Heart Failure 05/2024 - 11/2004
100	Cardiovascular Diseases (Cardiovascular Disease) 02/2024 - 10/2002
79	Myocardial Infarction 01/2024 - 02/2004
77	Atrial Fibrillation 11/2023 - 10/2004
58	Inflammation (Inflammations) 02/2024 - 01/2004
54	Ischemia 01/2022 - 03/2002
48	Hypertension (High Blood Pressure) 04/2024 - 11/2003
45	Coronary Artery Disease (Coronary Atherosclerosis) 11/2023 - 12/2003
44	Fibrosis (Cirrhosis) 05/2024 - 02/2004
37	Atherosclerosis 12/2023 - 11/2003
32	Chronic Renal Insufficiency 05/2024 - 07/2009
29	Obesity 02/2023 - 09/2006
25	Thrombosis (Thrombus) 05/2024 - 12/2002
23	Hypertrophy 01/2022 - 07/2005
23	Left Ventricular Dysfunction 01/2021 - 02/2004
22	Hemorrhage 01/2023 - 07/2012
22	Insulin Resistance 01/2023 - 12/2004
21	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 08/2023 - 11/2004
21	Type 2 Diabetes Mellitus (MODY) 01/2023 - 05/2007
21	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 04/2006
20	Hypoxia (Hypoxemia) 03/2024 - 01/2003
20	Body Weight (Weight, Body) 08/2023 - 06/2003
20	ST Elevation Myocardial Infarction 09/2022 - 08/2005
19	Diabetes Mellitus 01/2023 - 01/2004
17	Stroke (Strokes) 01/2024 - 08/2010
17	Acute Coronary Syndrome 08/2023 - 11/2004
16	Cardiomegaly (Heart Hypertrophy) 05/2024 - 06/2003
16	Death (Near-Death Experience) 11/2023 - 11/2004
16	Myocardial Ischemia (Ischemic Heart Diseases) 12/2021 - 10/2005
16	Atherosclerotic Plaque (Atheroma) 01/2020 - 01/2008
15	Peripheral Arterial Disease 12/2023 - 07/2008
15	Neoplasms (Cancer) 05/2023 - 07/2003
13	Ventricular Tachycardia 03/2024 - 07/2008
13	Chronic Limb-Threatening Ischemia 11/2022 - 09/2006
13	Infarction (Infarctions) 07/2020 - 02/2004
11	Glucose Intolerance 08/2017 - 03/2004
10	Cardiac Arrhythmias (Arrythmia) 02/2023 - 08/2009
10	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2021 - 07/2003
10	Neointima 12/2019 - 01/2005
9	Cardiogenic Shock 01/2024 - 01/2020
9	Pulmonary Arterial Hypertension 01/2023 - 06/2014
9	Reperfusion Injury 12/2018 - 02/2006
9	Stable Angina 02/2017 - 03/2006
8	Myocarditis (Carditis) 01/2024 - 07/2015
8	Heart Diseases (Heart Disease) 02/2023 - 06/2006
8	Pathologic Constriction (Stenosis) 01/2023 - 01/2004
8	Vascular Diseases (Vascular Disease) 01/2020 - 03/2006

Drug/Important Bio-Agent (IBA)

42	Proteins (Proteins, Gene)FDA Link 12/2023 - 01/2003
38	AdiponectinIBA 08/2023 - 04/2006
36	LipidsIBA 08/2023 - 06/2003
28	SaltsIBA 02/2024 - 10/2005
26	omega-Chloroacetophenone (Mace)IBA 01/2024 - 11/2004
21	AdipokinesIBA 02/2023 - 05/2011
19	Angiotensin Receptor AntagonistsIBA 04/2024 - 12/2003
19	Biomarkers (Surrogate Marker)IBA 04/2024 - 07/2009
19	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2003
18	AnticoagulantsIBA 03/2024 - 06/2005
18	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 08/2006
17	C-Reactive ProteinIBA 11/2023 - 04/2006
16	HDL CholesterolIBA 01/2020 - 06/2007
15	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022 - 06/2006
13	Matrix Metalloproteinases (MMPs)IBA 01/2022 - 02/2004
12	Warfarin (Coumadin)FDA LinkGeneric 11/2023 - 02/2013
12	Brain Natriuretic Peptide (Natrecor)FDA Link 10/2023 - 06/2006
12	oxidized low density lipoproteinIBA 06/2023 - 09/2004
12	Angiotensin IIIBA 01/2022 - 03/2002
11	Messenger RNA (mRNA)IBA 07/2022 - 02/2004
11	ApolipoproteinsIBA 01/2022 - 10/2003
11	Oxygen (Dioxygen)IBA 12/2021 - 08/2002
10	Antihypertensive Agents (Antihypertensives)IBA 11/2023 - 04/2006
10	Indicators and Reagents (Reagents)IBA 06/2023 - 10/2008
10	CytokinesIBA 10/2020 - 02/2004
9	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 04/2024 - 11/2006
9	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2017 - 02/2008
9	Sirolimus (Rapamycin)FDA Link 10/2013 - 11/2006
9	MetalsIBA 10/2013 - 03/2006
8	Sodium-Glucose Transporter 2 InhibitorsIBA 04/2024 - 01/2016
8	cathepsin SIBA 08/2023 - 11/2006
8	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 08/2023 - 05/2010
8	Uric Acid (Urate)IBA 06/2023 - 04/2009
8	Serum AlbuminIBA 01/2021 - 01/2012
8	Dobutamine FDA LinkGeneric 01/2020 - 11/2008
8	erucylphosphocholineIBA 11/2019 - 01/2003
8	LDL CholesterolIBA 01/2019 - 12/2010
8	pitavastatin (itavastatin)FDA Link 01/2018 - 06/2006
8	Insulin (Novolin)FDA Link 01/2018 - 12/2004

Therapy/Procedure

86	Therapeutics 05/2024 - 02/2006
70	Percutaneous Coronary Intervention 03/2024 - 11/2004
47	Catheter Ablation 03/2024 - 03/2006
38	Stents 12/2022 - 01/2004
33	Renal Dialysis (Hemodialysis) 12/2023 - 08/2006
15	Catheters 06/2023 - 07/2004
15	Drug-Eluting Stents 01/2023 - 12/2009
14	Cardiac Resynchronization Therapy 10/2022 - 10/2006
12	Patient Readmission 03/2023 - 08/2005
11	Heart-Assist Devices 01/2024 - 02/2020
11	Extracorporeal Membrane Oxygenation 02/2023 - 01/2018
10	Ligation 02/2023 - 02/2004
9	Surgical Amputation (Amputations) 12/2023 - 11/2008
8	Transcatheter Aortic Valve Replacement 05/2024 - 01/2021